Linkage Projects - Grant ID: LP0347705

Funded Activity Summary

The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering of downstream signalling molecules at sites of engagement with the extracellular matrix. In addition, we have found that cells presented with an extracellular matrix respond better to subsequent growth factor stimulation. The project aims to determine the cellular mechanisms underlying receptor clustering and the basis of the receptor-extracellular matrix interaction. This will enhance our understanding of growth factor function in a number of conditions, including wound healing. We will extend our in vitro results to the animal model to define parameters for enhanced wound repair.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2006

Funding Scheme: Linkage Projects

Funding Amount: $84,099.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

Skin and related disorders | Endocrine organs and diseases (incl. diabetes) | Cancer and related disorders |

Other Keywords

Biochemistry and Cell Biology | Cancer and related disorders | Cell Development (Incl. Cell Division And Apoptosis) | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Endocrine organs and diseases (incl. diabetes) | Protein Targeting And Signal Transduction | Skin and related disorders

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