Linkage Projects - Grant ID: LP0215935

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP0215935

Funding Status
Closed

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Funded Activity Summary

Enhanced biocatalysis in organic solvents for pharmaceutical biotransformation. Enzymes such as hydrolases play an important role in biotechnology because of their extreme versatility with respect to substrate specificity and stereoselectivity. The use of lipases as catalysts for optical isomer-specific organic reactions is often limited by unacceptably low enantioselectivities. We will investigate recombinant enzymes cloned from thermophilic lipolytic bacteria for synthetic reactions in organic solvents, especially chiral resolution of mixtures in the production of pharmaceutical intermediates. Genetic improvement of lipase enantiospecificity and regioselectivity will be achieved using in vitro evolution by recombination and screening. The outcome will be cost-effective production superior biocatalysts with specifically enhanced regiospecific, enantioselective and hydrolytic characteristics.

Funded Activity Details

Start Date: 01-01-2002

End Date: 31-12-2005

Funding Scheme: Linkage Projects

Funding Amount: $270,184.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Agricultural Biotechnology | Molecular Evolution | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Genetic Engineering And Enzyme Technology |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences | Chemical sciences

Other Keywords

Agricultural Biotechnology | Biological sciences | Chemical sciences | Genetic Engineering And Enzyme Technology | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Molecular Evolution | Treatments (e.g. chemicals, antibiotics)

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