Linkage Infrastructure, Equipment and Facilities - Grant ID: LE180100026

Funded Activity Summary

Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability. This project aims to extend an existing nuclear magnetic resonance (NMR) spectrometer for structural investigations of proteins in the solid state. Many proteins, such as amyloids and flexible proteins, cannot be studied by X-ray crystallography, solution NMR spectroscopy or cryoelectron microscopy, because they cannot be crystallised or are not sufficiently soluble, or are structurally too heterogeneous. This project will extend the capability of an existing 800 MHz NMR spectrometer to solid-state NMR. By offering ultrafast magic angle spinning speeds, the system aims to afford greatly enhanced sensitivity and multidimensional NMR spectra of protein systems not previously amenable to structural analysis by NMR spectroscopy or other techniques. This will have important applications in biotechnology and biomedicine.

Funded Activity Details

Start Date: 12-04-2018

End Date: 21-12-2020

Funding Scheme: Linkage Infrastructure, Equipment and Facilities

Funding Amount: $178,839.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Chemistry and Spectroscopy | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Neurodegenerative Disorders Related to Ageing | Human Pharmaceutical Treatments (e.g. Antibiotics) |

Other Keywords

Biochemistry and Cell Biology | Human Pharmaceutical Treatments (e.g. Antibiotics) | Neurodegenerative Disorders Related to Ageing | Structural Biology (incl. Macromolecular Modelling) | Structural Chemistry and Spectroscopy

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