ARC Future Fellowships - Grant ID: FT200100572

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT200100572

Funding Status
Active

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Funded Activity Summary

Molecular basis of nucleotide signalling by TIR domain containing proteins. Nicotinamide adenine dinucleotide (NAD+) dependent signalling pathways play important roles in neurodegenerative diseases and bacterial defence systems, and are therefore potential targets for the development of new therapeutics and biotechnology tools. This project aims to increase our understanding of the biology of a novel class of enzymes involved in NAD+ signalling across the domains of life. The project is expected to unravel general principles of nucleotide-based signalling, and the expected outcomes will include new molecular mechanisms relevant to cell-death and pathogen defence in mammalian and bacterial systems, which should provide significant benefit for a range of applications in human biology and biotechnology.

Funded Activity Details

Start Date: 04-01-2021

End Date: 03-01-2025

Funding Scheme: ARC Future Fellowships

Funding Amount: $818,952.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Innate Immunity | Structural Biology (incl. Macromolecular Modelling)

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