ARC Future Fellowships - Grant ID: FT150100049

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT150100049

Funding Status
Closed

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Funded Activity Summary

Understanding pore formation by the complement membrane attack complex. The project aims to improve our understanding of the function of the membrane attack complex (MAC). MAC is a large protein complex used by the human immune system to target invading bacteria and parasites by punching holes in the lipid membranes of target cells. The MAC is part of a superfamily of proteins, the MACPF (membrane attack complex/perforin superfamily)/CDC (cholesterol-dependent cytolysins) superfamily, used by animals (in venoms and immunity), fungi (in defence) and pathogenic bacteria (in disease). The aim of this project is to image to the highest possible resolution how the MAC form pores in the context of bacterial cells and explore the way it inserts into cells in real time. Intended project outcomes may lay the foundation for applied future research into improved antibiotic delivery and novel pesticide development.

Funded Activity Details

Start Date: 30-06-2016

End Date: 31-12-2021

Funding Scheme: ARC Future Fellowships

Funding Amount: $800,960.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules | Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Infectious Diseases

Other Keywords

Biochemistry and Cell Biology | Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Immune System and Allergy | Infectious Diseases | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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