ARC Future Fellowships - Grant ID: FT140101059

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT140101059

Funding Status
Closed

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Funded Activity Summary

Anticipating, Combating and Exploiting the Evolution of Pesticide Resistance in Australian Agricultural Pests and Disease Vectors. Synthetic insecticides have resulted in an explosion in food production through effective insect control. However, insects have begun to evolve resistance against one of the most widely used classes of insecticides (organophosphates) via mutations in carboxylesterases (CBEs). To address this problem, the ability to anticipate further evolution, combat it and exploit it for our own benefit is needed. This project aims to anticipate evolution by simulating it in the laboratory, allowing for the best preparation for change. New pesticides will be designed to combat insecticide resistance based upon the molecular structure of an insect CBE. This project aims to exploit these newly evolved enzymes to create biosensors and decontamination agents.

Funded Activity Details

Start Date: 01-01-2015

End Date: 31-12-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $772,104.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Synthetic Biology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Animal Protection Chemicals | Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Protection Chemicals | Biochemistry and Cell Biology | Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Structural Biology (incl. Macromolecular Modelling) | Synthetic Biology

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