ARC Future Fellowships - Grant ID: FT140101029

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT140101029

Funding Status
Closed

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Funded Activity Summary

Genetic control of germline progenitor cell heterogeneity and fate. Tissue maintenance in adults is dependent on resident stem cells, defined by self-renewal and differentiation capabilities. It is apparent that stem cell populations are heterogeneous, being composed of subpopulations with distinct properties. The functional significance of these subsets and mechanisms that control their divergent characteristics are unclear. Using germline stem cells from mice as a model, stem cell subsets have been identified based on differential expression of the pluripotency gene Pou5f1. This project aims to define functional characteristics of these subpopulations and to dissect transcription factor networks controlling their development. This promises important insights into understandings of adult stem cell regulation.

Funded Activity Details

Start Date: 01-07-2014

End Date: 31-12-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $771,700.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination) | Gene Expression (incl. Microarray and other genome-wide approaches) | Cell Development, Proliferation and Death | Genetics

ANZSRC Socio-Economic Objective (SEO)

Animal Production and Animal Primary Products not elsewhere classified | Expanding Knowledge in the Biological Sciences |

Other Keywords

Animal Production and Animal Primary Products not elsewhere classified | Cell Development, Proliferation and Death | Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics

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