ARC Future Fellowships - Grant ID: FT140100114

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT140100114

Funding Status
Closed

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Funded Activity Summary

Understanding endogenous allosteric modulators of G protein-coupled receptors. Major life science challenges include how chemicals outside cells signal to proteins inside, how this results in physiological responses, and how dysfunction of these processes leads to pathophysiology. Despite the critical importance of G protein-coupled receptors (GPCRs), much remains to be learned about their regulation by endogenous and synthetic molecules. This project aims to address this gap, by building on recent ground-breaking studies that have been performed, by focusing on alternative binding sites of GPCRs called allosteric sites. The major hypothesis is that these allosteric sites are widespread across GPCRs because the body produces endogenous allosteric ligands that remain largely unidentified, but which can play vital roles in biology.

Funded Activity Details

Start Date: 01-09-2014

End Date: 31-08-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $770,054.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Basic Pharmacology | Receptors and Membrane Biology | Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Respiratory System and Diseases (incl. Asthma) | Immune System and Allergy | Infectious Diseases

Other Keywords

Basic Pharmacology | Immune System and Allergy | Infectious Diseases | Pharmacology and Pharmaceutical Sciences | Receptors and Membrane Biology | Respiratory System and Diseases (incl. Asthma) | Signal Transduction

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