ARC Future Fellowships - Grant ID: FT130101417

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130101417

Funding Status
Closed

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Funded Activity Summary

EGFR-directed radioimmunotherapy combined with chemotherapy and DNA repair inhibition: development towards clinical application for aggressive cancers. Pancreatic ductal adenocarcinoma (PDAC) and triple negative breast cancer (TNBC) are aggressive diseases which lack effective therapies in clinical use. A novel and curative therapy was developed against PDAC and TNBC which involves targeted radiotherapy combined with chemotherapy and DNA damage response inhibition. This project will develop a “preclinical data package” comprising a biological rationale and preclinical evidence of safety and efficacy that together would justify an early phase clinical trial. This package includes the choice of formulations, mechanism of action and safety studies. This development will have an immediate impact for PDAC and TNBC patients and a future impact on other EGFR-positive cancers.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2017

Funding Scheme: ARC Future Fellowships

Funding Amount: $752,067.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Solid Tumours | Molecular Targets | Cancer Therapy (excl. Chemotherapy and Radiation Therapy) | Oncology and Carcinogenesis |

ANZSRC Socio-Economic Objective (SEO)

Cancer and Related Disorders | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Cancer Therapy (excl. Chemotherapy and Radiation Therapy) | Cancer and Related Disorders | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Molecular Targets | Oncology and Carcinogenesis | Solid Tumours

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