ARC Future Fellowships - Grant ID: FT130101289

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130101289

Funding Status
Closed

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Funded Activity Summary

mTOR signalling in serous ovarian cancer. Serous ovarian cancer is the most aggressive and lethal gynaecological cancer in Australian women. Activation of Mammalian Target of Rapamycin (mTOR) is frequently observed and associated with poor prognosis in ovarian cancer patients. However, the mechanisms dysregulating mTOR in the pathogenesis of ovarian cancer are unknown. In preliminary studies, deletion of genes regulating mTOR signalling in up to 60 per cent of human serous ovarian cancer patients was observed. This project will provide mechanistic details of involvement of mTOR signalling in pathogenesis of the serous ovarian carcinoma, and develop a rationale for targeting mTOR pathway in these patients.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2017

Funding Scheme: ARC Future Fellowships

Funding Amount: $749,814.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis | Cancer Genetics | Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

Cancer and Related Disorders |

Other Keywords

Cancer Cell Biology | Cancer Genetics | Cancer and Related Disorders | Oncology and Carcinogenesis

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