ARC Future Fellowships - Grant ID: FT130100988

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100988

Funding Status
Closed

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Funded Activity Summary

Novel mechanisms controlling signaling by adenosine monophosphate-activated protein kinase, central regulator of energy homeostasis. Sedentary lifestyles and consumption of high energy foods have led to dramatic increases in the incidence of obesity-related metabolic diseases such as type 2 diabetes and cardiovascular disease, placing enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK), which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Building on recent breakthroughs made at St. Vincent's Institute, this project will produce innovative research into novel mechanisms that control AMPK. These discoveries will greatly increase our understanding of AMPK regulation by cellular processes, and aid the design of more effective AMPK drugs.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2017

Funding Scheme: ARC Future Fellowships

Funding Amount: $727,370.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Signal Transduction | Structural Biology (incl. Macromolecular Modelling) | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Diabetes | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cardiovascular System and Diseases | Cell Metabolism | Diabetes | Expanding Knowledge in the Biological Sciences | Signal Transduction | Structural Biology (incl. Macromolecular Modelling)

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