ARC Future Fellowships - Grant ID: FT130100781

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100781

Funding Status
Closed

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Funded Activity Summary

Understanding the mechanisms of ion conduction and drug action in voltage gated sodium channels. Voltage-gated sodium channels initiate electrical impulses in nerve and muscle and are the target of many local anaesthetic, anti-epileptic and anti-arrythmic drugs. The publication of atomic resolution structures of homologous proteins from bacteria in the last 18 months has now made it possible to gain a detailed understanding of how these channels work, and how they are influenced by drugs. This project aims to determine the basis of ion permeation and selectivity in the channels and explain the mechanisms of action for a number of common drugs. This will provide a foundation for future drug development to target specific channels for improved treatment of epilepsy, chronic pain and arrythmias.

Funded Activity Details

Start Date: 10-02-2014

End Date: 22-09-2020

Funding Scheme: ARC Future Fellowships

Funding Amount: $693,593.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Physiology | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular System and Diseases | Nervous System and Disorders | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Cardiovascular System and Diseases | Cell Physiology | Expanding Knowledge in the Biological Sciences | Nervous System and Disorders | Neurology and Neuromuscular Diseases | Structural Biology (incl. Macromolecular Modelling)

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