ARC Future Fellowships - Grant ID: FT130100580

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100580

Funding Status
Closed

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Funded Activity Summary

How Bacteria Fold Virulence Factors to Cause Disease. Bacteria use folding enzymes to assemble proteins essential for cell integrity and pathogenicity. These foldases include the Disulphide bridge proteins, which catalyse the introduction of disulfide bonds. This project will study two important human pathogens, Salmonella Typhimurium and uropathogenic Escherichia coli, to address the fundamental and poorly understood questions of diversity of Dsb networks across bacterial pathogens and the role of these foldases in virulence. The research will reveal how bacterial virulence factors are folded, identify novel targets for therapeutic intervention and provide the basis for structure-based design on new antimicrobials in the future.

Funded Activity Details

Start Date: 01-04-2014

End Date: 31-12-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $749,153.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Infectious Diseases |

Other Keywords

Bacteriology | Biochemistry and Cell Biology | Enzymes | Expanding Knowledge in the Biological Sciences | Infectious Diseases | Structural Biology (incl. Macromolecular Modelling)

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