ARC Future Fellowships - Grant ID: FT130100518

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100518

Funding Status
Closed

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Funded Activity Summary

Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM remodelling. Previous studies have developed a unique mouse model of childhood asthma and discovered the molecular mechanism by which this tissue tropism develops in response to virus infection. This project will identify new targets for immunomodulation and design new biologics to block ASM remodelling and the deleterious effects of respiratory virus infection in asthmatic subjects.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $754,320.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology - Systems | Allergy | Immunology | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Respiratory System and Diseases (incl. Asthma) | Immune System and Allergy | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Allergy | Animal Physiology - Systems | Expanding Knowledge in the Medical and Health Sciences | Immune System and Allergy | Immunology | Innate Immunity | Respiratory System and Diseases (incl. Asthma)

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