ARC Future Fellowships - Grant ID: FT130100166

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100166

Funding Status
Closed

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Funded Activity Summary

Molecular Mechanisms of NOD signalling. Alterations in NOD1 and NOD2 (nucleotide-binding oligomerization domain containing 1 and 2) signalling have been implicated in various human inflammatory diseases. Therefore, a clear understanding of the molecular signalling pathways is important to gain further insights into potential drug targets for the treatment of these diseases. Using novel experimental approaches, this project aims to identify new members of the NOD signalling pathway. It will test the effect of pharmacological inhibition of established molecules such as RIPK2 or IAPs in NOD dependent models for human diseases. Outcomes of this study will be of the utmost interest for the treatment of NOD driven diseases such as Crohn's disease, Blau syndrome or asthma.

Funded Activity Details

Start Date: 01-01-2014

End Date: 31-12-2017

Funding Scheme: ARC Future Fellowships

Funding Amount: $731,320.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology | Signal Transduction | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Respiratory System and Diseases (incl. Asthma) | Immune System and Allergy | Infectious Diseases |

Other Keywords

Immune System and Allergy | Immunology | Infectious Diseases | Innate Immunity | Respiratory System and Diseases (incl. Asthma) | Signal Transduction

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