ARC Future Fellowships - Grant ID: FT130100150

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100150

Funding Status
Closed

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Funded Activity Summary

New platform technologies for the chemical synthesis of post-translationally modified proteins. The last decade has seen an explosion in the number of protein drugs approved for use in the clinic, a large proportion of which possess post-translational modifications (PTMs). These modified protein drugs are produced and sold as mixtures which has led to difficulties in understanding the role of specific PTMs on activity and in gaining clinical approval for candidate drugs. This project will provide a fundamental solution to this problem through the development of novel synthetic methods and a powerful new platform technology for accessing PTM proteins in pure form. The utility of this technology will be demonstrated through its use in the total chemical synthesis of a range of PTM proteins for applications in biology and medicine.

Funded Activity Details

Start Date: 02-05-2014

End Date: 01-06-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $872,040.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Organic Chemistry | Organic Chemical Synthesis | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Immune System and Allergy |

Other Keywords

Biologically Active Molecules | Expanding Knowledge in the Chemical Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Immune System and Allergy | Organic Chemical Synthesis | Organic Chemistry | Proteins and Peptides

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