ARC Future Fellowships - Grant ID: FT130100138

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100138

Funding Status
Closed

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Funded Activity Summary

Herpesvirus entry into mammalian hosts. Herpesviruses infect most mammals and cause much chronic disease. Our poor understanding of their host entry pathways limits infection control. The olfactory neuroepithelium has been identified as a key entry portal for both a murid herpesvirus and a human pathogen, Herpes simplex virus, suggesting that many herpesviruses use this route. Virions cross the olfactory mucus on neuronal cilia, then either infect neurons or transfer to glial cells for local spread. This project will identify key receptor interactions and map the extent of invasion. By advancing our basic understanding of these important viruses and their uptake at an abundantly exposed but little explored anatomical site, the project can establish a basis for vaccinating against chronic disease.

Funded Activity Details

Start Date: 01-03-2014

End Date: 31-12-2018

Funding Scheme: ARC Future Fellowships

Funding Amount: $852,240.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural Immunology and Immunochemistry | Preventive Medicine | Virology | Microbiology |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Disease Distribution and Transmission (incl. Surveillance and Response) | Infectious Diseases

Other Keywords

Disease Distribution and Transmission (incl. Surveillance and Response) | Expanding Knowledge in the Biological Sciences | Humoural Immunology and Immunochemistry | Infectious Diseases | Microbiology | Preventive Medicine | Virology

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