ARC Future Fellowships - Grant ID: FT130100103

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT130100103

Funding Status
Closed

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Funded Activity Summary

Breaking it down: Dissecting the mechanism and exploring new inhibition strategies for polysaccharide cleaving enzymes. Mannose, a common carbohydrate building block, is present in a wide variety of complex polysaccharides including energy storage polymers and glycans attached to proteins. The enzymes that degrade these mannose-rich polymers, termed mannosidases, are important in biofuel production and human health and disease. This project will study a range of mannosidases to chemically and structurally define their mechanisms and establish strategies to allow intervention in mannosidase-specific disease processes. This work will inform strategies to engineer new enzymes for future biotechnology and industrial applications including sustainable chemical manufacturing, and underpin the development of innovative drugs for treating fungal infections and cancer.

Funded Activity Details

Start Date: 01-02-2014

End Date: 31-12-2017

Funding Scheme: ARC Future Fellowships

Funding Amount: $872,240.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Organic Chemistry | Organic Chemical Synthesis | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Biofuel (Biomass) Energy | Cancer and Related Disorders | Environmentally Sustainable Manufacturing not elsewhere classified |

Other Keywords

Biofuel (Biomass) Energy | Biologically Active Molecules | Cancer and Related Disorders | Environmentally Sustainable Manufacturing not elsewhere classified | Organic Chemical Synthesis | Organic Chemistry

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