ARC Future Fellowships - Grant ID: FT0992234

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/FT0992234

Funding Status
Closed

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Funded Activity Summary

Role of Histone deacetylase 3 (HDAC3) in intestinal epithelial cell homeostasis and tumorigenesis. Colon cancer is the most common cancer that affects men and women in Australia. Annually, in Victoria alone, more than 3400 people are diagnosed with colon cancer. Colon cancer arises through the accumulation of mutations in key genes over time. Identification of cancer causing genes provides the basis for the design of new cancer therapies. We recently identified a gene called Histone deacetylase 3 (HDAC3) as potentially involved in promoting colon cancer. The current proposal will now extend and validate this finding in mice. Importantly, drugs which inhibit HDAC3 have recently been developed for the treatment of cutaneous T-cell lymphoma. Defining the role HDAC3 plays in colon cancer will justify testing these drugs in colon cancer patients.

Funded Activity Details

Start Date: 01-07-2009

End Date: 31-12-2013

Funding Scheme: ARC Future Fellowships

Funding Amount: $686,400.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Oncology And Carcinogenesis | Cell Development (Incl. Cell Division And Apoptosis) | Animal Physiology—Cell

ANZSRC Socio-Economic Objective (SEO)

Digestive system and disorders | Cancer and related disorders |

Other Keywords

Animal Physiology—Cell | Biochemistry and Cell Biology | Cancer and related disorders | Cell Development (Incl. Cell Division And Apoptosis) | Digestive system and disorders | Oncology And Carcinogenesis

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