Discovery Projects - Grant ID: DP240103205

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240103205

Funding Status
Active

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Funded Activity Summary

Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $526,047.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Structural biology (incl. macromolecular modelling) | Molecular imaging (incl. electron microscopy and neutron diffraction) | Biological physics

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Biological physics | Expanding Knowledge In the Biological Sciences | Molecular imaging (incl. electron microscopy and neutron diffraction) | Structural biology (incl. macromolecular modelling)

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