Discovery Projects - Grant ID: DP240102611

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240102611

Funding Status
Active

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Funded Activity Summary

Nuclear RNA surveillance and its connection to splicing quality control. Due to the error-prone nature of RNA splicing, elaborate quality control processes ensure that only correctly spliced transcripts can leave the nucleus. It has long been known that incorrectly spliced mRNA transcripts are degraded by the nuclear RNA surveillance machinery, but how the RNA quality control machinery is connected to nuclear RNA surveillance is not known. This proposal aims to uncover the connection between these two important processes and will fill a significant gap in our understanding of how splicing quality control and nuclear RNA surveillance work. The project will also identify sequence features that trigger abortive splicing reactions and will thus help to improve the design of synthetic mRNAs.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $507,424.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene expression (incl. microarray and other genome-wide approaches) | Genomics and transcriptomics | Structural biology (incl. macromolecular modelling) | Genetics |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Expanding Knowledge In the Biological Sciences | Gene expression (incl. microarray and other genome-wide approaches) | Genetics | Genomics and transcriptomics | Structural biology (incl. macromolecular modelling)

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