Discovery Projects - Grant ID: DP240102097

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240102097

Funding Status
Active

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Funded Activity Summary

Defining a new family of sodium channel accessory proteins. Voltage-gated sodium channels are key proteins that function as multi-subunit complexes to regulate neuronal excitability. The project aims to investigate the structure and function of a novel family of accessory subunits by utilizing a class of toxins, derived from the giant Australian stinging tree, that directly binds to these proteins to modulate sodium channel function. The project aims to generate significant new knowledge on the function of sodium channels as multi-protein complexes. Expected outcomes of this project include development of novel channel-modulating molecules that may have applications as neuroscience tools to address fundamental questions about ion channel function and biology.

Funded Activity Details

Start Date: 25-01-2024

End Date: 24-01-2027

Funding Scheme: Discovery Projects

Funding Amount: $615,493.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biologically active molecules | Medicinal and biomolecular chemistry | Proteins and peptides | Receptors and membrane biology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biologically active molecules | Expanding Knowledge In the Biological Sciences | Expanding Knowledge In the Chemical Sciences | Medicinal and biomolecular chemistry | Proteins and peptides | Receptors and membrane biology

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