Discovery Projects - Grant ID: DP240102085

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240102085

Funding Status
Active

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Funded Activity Summary

Hyperactive endogenous retroviruses and their impact on the koala genome. Koala populations are in steep decline with the ubiquitous koala retrovirus (KoRV) strongly linked with disease. KoRV and other less studied endogenous retrovirus (ERVs) are extremely active within the genome of koalas to a level never observed in any other vertebrate genome. This study will map ERV integration sites within koalas from across their geographic range country and use long-read genomics approaches to understand the link between KoRV and other ERVs, the impact on koala caused by dramatic genomic rewiring, and the mechanisms of genomic immunity which supress ERV activity and mitigate disease. Findings will provide insights into the ongoing arms race between virus and host and inform conservation of an iconic species.

Funded Activity Details

Start Date: 05-02-2024

End Date: 04-02-2027

Funding Scheme: Discovery Projects

Funding Amount: $593,530.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Microbiology | Genomics | Virology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Expanding Knowledge In the Biological Sciences | Genomics | Microbiology | Terrestrial Biodiversity | Virology

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