Discovery Projects - Grant ID: DP240101768

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240101768

Funding Status
Active

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Funded Activity Summary

Novel mechano-signalling pathways at sites of cellular adhesion. Piezo channels are membrane proteins that detect mechanical cues and underlie our sense of touch. We aim to characterize the first protein regulator of Piezo channels by developing and utilizing novel technologies including acoustic forces to monitor Piezo channel function. The significance of this study is underscored by the wide spread expression of Piezo channels and their involvement in many cellular processes. Expected outcomes are novel technologies to study mechanobiology, patentable peptide-based Piezo modulators and a new conceptual paradigm for understanding cellular mechanosensing. This knowledge will benefit a broad scientific community through technological advancements and pharmacological agents to manipulate Piezo channels.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $597,127.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell physiology | Biochemistry and cell biology | Signal transduction |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cell physiology | Expanding Knowledge In the Biological Sciences | Expanding Knowledge In the Physical Sciences | Signal transduction

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