Discovery Projects - Grant ID: DP240101665

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240101665

Funding Status
Active

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Funded Activity Summary

Understanding T cell trafficking and function during antigenic interference. Science generally studies antigenic stimulation in isolation, by measuring immunity towards antigens derived from a single pathogen. However, as mammals can harbour more than one infection at any given time, we established a model of antigenic interference using different antigens derived from two unrelated pathogens, influenza A (IAV) and Semliki Forest virus (SFV). Our data show that prior exposure to either IAV or SFV greatly perturbs T cell dynamics. This proposal will study, at cellular and molecular levels, T cell trafficking, function and clonal distribution during antigenic interference, thus advance fundamental knowledge on T cell immunity during antigenic competition, and provide a new paradigm on how we research T cell immunity.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $792,223.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular immunology | Biochemistry and cell biology | Cell development proliferation and death | Receptors and membrane biology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cell development proliferation and death | Cellular immunology | Expanding Knowledge In the Biological Sciences | Receptors and membrane biology

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