Discovery Projects - Grant ID: DP240101399

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240101399

Funding Status
Active

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Funded Activity Summary

High-throughput single-molecule directed evolution. DNA polymerases are essential enzymes in many biotechnological tools, including DNA sequencing and PCR tests. However, existing DNA polymerases have limitations, resulting in inaccuracies and inefficiencies. Existing methods to improve polymerases lack sensitivity to screen for subtle, yet pivotal traits. This project aims to overcome this limitation by developing a new single-molecule directed-evolution system to evolve better polymerases. With this new technology we aim to identify DNA polymerases with improved performance that benefit biotechnological applications. Additionally, these single-molecule directed-evolution methods will benefit the wider scientific community and lay the foundation for further advances in directed evolution.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $598,737.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of biological macromolecules | Enzymes | Biochemistry and cell biology | Molecular evolution |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Characterisation of biological macromolecules | Diagnosis of Human Diseases and Conditions | Enzymes | Horticultural Crops Not Elsewhere Classified | Human Pharmaceutical Treatments | Molecular evolution

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