Discovery Projects - Grant ID: DP240101332

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240101332

Funding Status
Active

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Funded Activity Summary

Manipulation of mitochondrial function by Legionella pneumophila. . The intracellular bacterial pathogen Legionella pneumophila co-evolved with eukaryotic hosts and has developed sophisticated mechanisms to manipulate human cell function – mitochondria in particular – by secreting >300 effector proteins through a specialised Type-IV system into the host cell. This research aims to understand the function of effector proteins targeted to mitochondria; delivering important new knowledge in host-pathogen and mitochondrial biology and advanced cell biology tools. With most of the effector proteins yet to be characterised, benefits from the project will be to reveal specifically how these target mitochondria, and more broadly, how bacterial pathogens manipulate organelles for their survival.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $620,887.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein trafficking | Bacteriology | Biochemistry and cell biology | Cell metabolism |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Bacteriology | Biochemistry and cell biology | Cell metabolism | Expanding Knowledge In the Biological Sciences | Protein trafficking

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