Discovery Projects - Grant ID: DP240100815

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240100815

Funding Status
Active

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Funded Activity Summary

Decoding microtubule remodelling in sperm production. All eukaryotic cells possess a dynamic microtubule (MT) cytoskeleton, which requires constant remodelling to satisfy its many essential cellular roles. Emerging data suggests modifications to the MT surface (the tubulin code) may act as instructional signposts for remodelling. This project aims to define a fundamental component of the tubulin code, glutamylation, and define how this directs MT severing. It also aims to define the cellular functions of MT-severing enzyme FIGNL1 and key MT glutamylation enzymes (CCP1, CCP5 and TTLL1). Insights will be generated using sperm production as a model system and will thus inform the mechanisms by which fertile sperm are built, in addition to being relevant to cell biology across eukaryotic species.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2026

Funding Scheme: Discovery Projects

Funding Amount: $675,930.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal developmental and reproductive biology | Reproduction | Cell development proliferation and death | Reproductive medicine |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Animal developmental and reproductive biology | Cell development proliferation and death | Expanding Knowledge In the Agricultural, Food and Veterinary Sciences | Expanding Knowledge In the Biological Sciences | Reproduction | Reproductive medicine

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