Discovery Projects - Grant ID: DP240100514

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP240100514

Funding Status
Active

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Funded Activity Summary

Chemical staples and chemical probes to dissect dynamins cellular roles. Modulation of protein structure drives cellular function. Dynamin GTPase forms at least two macromolecular structures with different cellular functions. The drivers behind these different structures is unknown. In this project we will leverage our discoveries, and planned enhancements, of chemical biology probes that will modulate dynamin activity by inhibiting at three distinct sites, and one site that stimulates dynamin activity. It is known that Dynamin helices and rings are believed responsible for at least three in cell biological functions: in hormone, neutral and receptor internalisation; cellular mitosis and in actin dynamics. Prior to this work we have lacked the tools to understand the role of shape modulation of protein function.

Funded Activity Details

Start Date: 01-01-2024

End Date: 31-12-2028

Funding Scheme: Discovery Projects

Funding Amount: $1,031,345.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biologically active molecules | Protein trafficking | Biochemistry and cell biology | Cell development proliferation and death |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Biologically active molecules | Cell development proliferation and death | Expanding Knowledge In the Biological Sciences | Expanding Knowledge In the Chemical Sciences | Protein trafficking

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