Discovery Projects - Grant ID: DP230103193

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230103193

Funding Status
Active

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Funded Activity Summary

How are sperm mitochondria eliminated after fertilisation . The fact that mitochondria are inherited exclusively through the maternal germ-line is fundamental feature of sexual reproduction in all but a few organisms. This uni-parental inheritance is thought to prevent genetic conflict between different mitochondrial genomes. The mechanisms controlling uniparental inheritance involve eliminating the sperm mitochondria soon after fertilisation. We will investigate 2 possible mechanisms, (1) active destruction and (2) passive dilution. The results will help explain how heteroplasmy is avoided in order to maintain the fitness of organisms including animals and humans. The results will have long term insights into improving breeding in agriculture and in the prevention of mitochondrial genetic disease.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Projects

Funding Amount: $428,988.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal developmental and reproductive biology | Cell metabolism | Cell development proliferation and death | Zoology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Animal developmental and reproductive biology | Cell development proliferation and death | Cell metabolism | Expanding Knowledge In the Biological Sciences | Zoology

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