Discovery Projects - Grant ID: DP230103127

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230103127

Funding Status
Active

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Funded Activity Summary

Understanding why mammalian eggs have so much mitochondrial DNA . During oocyte growth there is massive increase in the replication of mitochondrial DNA so that each ovulated egg has 200,000-400,000 copies of the mitochondrial genome. This mitochondrial compliment will provide the template for all mitochondrial DNA in the subsequent organism. The established role of mitochondria is to provide energy in the form of ATP, but they are also known to be highly adaptive to the metabolic and energetic state of the cell. In this project, we will use genetic approaches to decrease the amount of oocyte mitochondrial DNA by 90%. We will examine how this influences mitochondrial organisation, oocyte metabolism and embryo development. This new knowledge will provide insights into animal breeding and human health.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Projects

Funding Amount: $405,823.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal developmental and reproductive biology | Cell metabolism | Cell development proliferation and death | Zoology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Animal developmental and reproductive biology | Cell development proliferation and death | Cell metabolism | Expanding Knowledge In the Biological Sciences | Zoology

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