Discovery Projects - Grant ID: DP230102958

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230102958

Funding Status
Active

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Funded Activity Summary

Molecular definition of cellular states in the vascular endothelium. The endothelium is the main cell type forming blood vessels and spans across multiple cell states from stem/progenitor to a variety of terminally differentiated cells. How each of these cell states are defined at the molecular level is not known preventing the optimal formation and integration of blood vessels in bioengineered tissues. Using innovative single cell gene expression and chromatin accessibility studies combined with innovative analysis, we propose to define and validate each cell state at the molecular level. This new knowledge would greatly enhance our ability to control the transition between cell states leading to a more widespread use of endothelial cells in bioengineering of tissues globally for many applications.

Funded Activity Details

Start Date: 19-01-2023

End Date: 18-01-2026

Funding Scheme: Discovery Projects

Funding Amount: $473,280.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene expression (incl. microarray and other genome-wide approaches) | Epigenetics (incl. genome methylation and epigenomics) | Genetics | Regenerative medicine (incl. stem cells)

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Epigenetics (incl. genome methylation and epigenomics) | Expanding Knowledge In Engineering | Expanding Knowledge In the Biological Sciences | Gene expression (incl. microarray and other genome-wide approaches) | Genetics | Regenerative medicine (incl. stem cells)

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