Discovery Projects - Grant ID: DP230102269

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230102269

Funding Status
Active

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Funded Activity Summary

Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a deeper understanding of this major brain compartment in neuronal function.

Funded Activity Details

Start Date: 01-04-2023

End Date: 31-03-2026

Funding Scheme: Discovery Projects

Funding Amount: $459,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular nervous system | Biochemistry and cell biology | Cellular interactions (incl. adhesion matrix cell wall) | Cell neurochemistry |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cell neurochemistry | Cellular interactions (incl. adhesion matrix cell wall) | Cellular nervous system | Expanding Knowledge In the Biological Sciences

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