Discovery Projects - Grant ID: DP230102105

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230102105

Funding Status
Active

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Funded Activity Summary

Redefining the immune landscape of the human ocular surface. At the ocular surface, the cornea and limbus need to mount effective immune responses to maintain corneal transparency for clear vision. The current paradigm is that the human cornea houses the same innate immune cell subsets (dendritic cells and macrophages) as naïve mice in pathogen-free facilities. Our pilot data challenge this premise, with early evidence that innate and adaptive cells (T cells) coexist in normal human corneas. Integrating state-of-the-art techniques, we will advance understanding of immune regulation at the human ocular surface by comprehensively defining immune cell biology and dynamics. We will define the effect of age on immune cells in these tissues, and relationships between the tear proteome and cell behaviours.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Projects

Funding Amount: $652,264.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular immunology | Sensory systems | Optical technology | Immunology |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Cellular immunology | Expanding Knowledge In the Biological Sciences | Immunology | Optical technology | Sensory systems

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