Discovery Projects - Grant ID: DP230100728

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230100728

Funding Status
Active

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Tuning the activating stimulus of voltage-gated sodium channels. This proposal aims to advance fundamental knowledge about how proteins (ion channels) found on the surface of neurons (brain cells and nerves) function as molecular conduits of cell-to-cell electrical communication. We aim to study how molecular probes and structural parts of these proteins affect the local chemical environment of ion channels, and how this leads to fine tuning of the ion channel's sensitivity to the stimulus that activates them (cell membrane voltage). The conceptual knowledge gained from this project would advance our understanding of a fundamental physiological process and facilitate the development of drugs that regulate ion channel function, such as anti-epileptics, analgesics and insecticides.

Funded Activity Details

Start Date: 19-01-2023

End Date: 18-01-2026

Funding Scheme: Discovery Projects

Funding Amount: $474,207.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Signal transduction | Receptors and membrane biology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Expanding Knowledge In the Biological Sciences | Receptors and membrane biology | Signal transduction

Related Links