Discovery Projects - Grant ID: DP230100415

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230100415

Funding Status
Active

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Funded Activity Summary

Advances in Peptide Synthesis: Exploiting Underutilised Functional Groups. The translation of therapeutically-relevant classes of peptides to the clinic is often limited by chemists' ability to synthesise these complex biomolecules efficiently and sustainably. This project aims to develop new tools for the preparation of designer peptides that are broadly inspired by an underutilised reactive group found in naturally-occurring peptide sequences. Expected outcomes encompass health and economic benefits for the Australian community, including: the first approach to a class of promising antibiotic peptide natural product analogues, the development of a mild electrochemical approach to peptide modification, and the production of a library of novel amino acids for incorporation into potential antibiotic leads.

Funded Activity Details

Start Date: 01-01-2023

End Date: 31-12-2025

Funding Scheme: Discovery Projects

Funding Amount: $424,590.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biologically active molecules | Organic chemical synthesis | Medicinal and biomolecular chemistry | Proteins and peptides |

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biologically active molecules | Expanding Knowledge In the Biological Sciences | Expanding Knowledge In the Chemical Sciences | Medicinal and biomolecular chemistry | Organic chemical synthesis | Proteins and peptides

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