Discovery Projects - Grant ID: DP230100393

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230100393

Funding Status
Active

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Funded Activity Summary

Adrenomedullin: a specific regulator of venous vessel integrity. Arteries and veins display different adhesive properties, which enable them to fulfil their physiological roles. We are yet to understand the mechanisms that establish and maintain adhesive function in different vessel types. We have discovered that signalling by the peptide Adrenomedullin (ADM) is a key mediator of adhesion, only in veins but not arteries. This project aims to utilise innovative models (zebrafish, mouse and bioengineered vessels) to identify the biochemical and mechanical mechanisms by which ADM controls venous adhesion. Outcomes will improve our understanding on how vessel integrity is controlled across vessel types and will expand the scope of Australian research by informing efforts to vascularise engineered tissues.

Funded Activity Details

Start Date: 19-01-2023

End Date: 18-01-2026

Funding Scheme: Discovery Projects

Funding Amount: $673,490.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Cellular interactions (incl. adhesion matrix cell wall) | Receptors and membrane biology | Mechanobiology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cellular interactions (incl. adhesion matrix cell wall) | Expanding Knowledge In the Biological Sciences | Mechanobiology | Receptors and membrane biology

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