Discovery Projects - Grant ID: DP230100379

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230100379

Funding Status
Active

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Funded Activity Summary

Glucocorticoid receptor-αD1 modulates stress and inflammation . Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using innovative molecular biology approaches, GRalphaD1's function will be examined to provide a deeper understanding of how stress regulates inflammation in animal reproduction. The project aims to enhance interdisciplinary collaborations with expected benefits including a paradigm shift in our knowledge in this field.

Funded Activity Details

Start Date: 30-03-2023

End Date: 29-03-2026

Funding Scheme: Discovery Projects

Funding Amount: $478,327.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal developmental and reproductive biology | Cell physiology | Animal reproduction and breeding | Medical physiology

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Animal developmental and reproductive biology | Animal reproduction and breeding | Cell physiology | Expanding Knowledge In the Biological Sciences | Medical physiology

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