Discovery Projects - Grant ID: DP230100300

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP230100300

Funding Status
Active

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Funded Activity Summary

Pyroptotic macrophages posthumously sculpt immune responses. The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to reveal precisely how cell death sculpts immune responses. Expected outcomes include new insights into how immune cells die, and how they instruct immune responses from beyond the grave. Project benefits include a fundamental understanding of how cell death signalling sculpts tissue immune responses, and knowledge of how to manipulate cell death responses for future basic research and commercial applications beyond this project.

Funded Activity Details

Start Date: 19-01-2023

End Date: 18-01-2026

Funding Scheme: Discovery Projects

Funding Amount: $570,250.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and cell biology | Cell development proliferation and death | Signal transduction

ANZSRC Socio-Economic Objective (SEO)

Other Keywords

Biochemistry and cell biology | Cell development proliferation and death | Expanding Knowledge In the Biological Sciences | Signal transduction

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