Discovery Projects - Grant ID: DP220103530

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP220103530

Funding Status
Active

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Funded Activity Summary

Using venoms to map critical and evolutionary conserved vulnerabilities. We have developed and applied new functional genomic approaches to study venom evolution. Using CRISPR screening, we find that unrelated venoms act on cells by exploiting the same vulnerabilities. By functionally mapping these vulnerabilities for all venom classes, we can begin to develop universal venom antidotes. Conversely, much of what we know about venom mechanisms comes from a small percentage of the biodiversity within a venom, and we have developed genomic tools to study the venom “dark matter”. This work will lead to the full molecular characterisation of venom biodiversity, and new venom components will be useful for research or as novel medicines.

Funded Activity Details

Start Date: 15-03-2022

End Date: 14-03-2025

Funding Scheme: Discovery Projects

Funding Amount: $528,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genomics | Molecular Evolution | Systems Biology | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Expanding Knowledge in the Biological Sciences | Genetics | Genomics | Molecular Evolution | Systems Biology

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