Discovery Projects - Grant ID: DP220103444

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP220103444

Funding Status
Active

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Funded Activity Summary

The control of cell signalling by membrane remodelling. Cells secrete signalling molecules called growth factors to drive critical developmental processes such as growth, differentiation and death. This project aims to understand a new mechanism that we have discovered for the control of growth factors by a protein family evolved to damage cell membranes. This is highly novel since the usual role of these proteins is to kill pathogens targeted by the immune system. By coupling innovative genetics, high-resolution imaging, and advanced biochemical analyses, this project intends to provide key molecular insights into how cell signalling can be regulated during animal development. We anticipate that this will impact our general understanding of membrane biology and its influence on cell signalling.

Funded Activity Details

Start Date: 24-02-2022

End Date: 23-02-2025

Funding Scheme: Discovery Projects

Funding Amount: $464,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination) | Biochemistry and Cell Biology not elsewhere classified | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology not elsewhere classified | Developmental Genetics (incl. Sex Determination) | Expanding Knowledge in the Biological Sciences | Genetics

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