Discovery Projects - Grant ID: DP220102511

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP220102511

Funding Status
Active

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Funded Activity Summary

How do protein quality control mechanisms maintain neuronal ageing? This project aims to interrogate how mechanisms of protein quality control act in the brain - an organ that is particularly vulnerable to a high load of misfolded protein - to maintain normal physiology during ageing. This project expects to make advances in cellular biochemistry and neuroscience, using an innovative proximity labelling approach to identify quality control regulators in neurons that specifically engage with misfolded proteins during ageing, within the nervous system of a living animal. Expected outcomes of this project will generate new knowledge of brain physiology and ageing relevant to all animals. This should provide significant benefits, such as a greater understanding of long-term brain functions including memory.

Funded Activity Details

Start Date: 17-06-2022

End Date: 16-06-2025

Funding Scheme: Discovery Projects

Funding Amount: $554,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Animal Neurobiology | Biochemistry and Cell Biology | Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

Nervous System and Disorders |

Other Keywords

Animal Neurobiology | Biochemistry and Cell Biology | Cell Neurochemistry | Nervous System and Disorders | Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

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