Discovery Projects - Grant ID: DP220102402

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP220102402

Funding Status
Active

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Funded Activity Summary

An investigation into CD1a, a versatile antigen-presenting molecule. This project aims to investigate how T lymphocytes are activated by lipids presented by the skin-associated antigen-presenting molecule, CD1a. Using X-ray crystallography and cellular immunology, we will provide fundamental insight into this poorly understood immunological axis. We will determine the molecular basis for how CD1a presents diverse self and foreign lipids, and how such CD1a-lipid complexes are recognised by the responding T cells. This basic science discovery project will provide substantial new knowledge in the burgeoning field of lipid-mediated immunity, which should ultimately lead to new therapies targeting the CD1a lipid display molecule to either prevent immune mediated damage or promote protective immunity as required.

Funded Activity Details

Start Date: 01-12-2022

End Date: 30-11-2025

Funding Scheme: Discovery Projects

Funding Amount: $574,386.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Immunology | Structural Biology (incl. Macromolecular Modelling) | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Cellular Immunology | Expanding Knowledge in the Biological Sciences | Immunology | Innate Immunity | Structural Biology (incl. Macromolecular Modelling)

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