Discovery Projects - Grant ID: DP220101352

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP220101352

Funding Status
Active

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Funded Activity Summary

How novel ribosomal RNA gene repeat variants drive cellular function. The hundreds of ribosomal RNA gene repeat copies are a remarkable part of our genomes, as they encode the machinery responsible for all cellular protein synthesis and shape the structure of the nucleus. However, due to their high degree of sequence similarity, they still have not been assembled into the human genome reference. This project will resolve this impasse and furthermore uncover the functional impacts of a newly identified molecular diversity in the ribosomal RNA gene repeats. Outcomes include new paradigms for how the ribosomal RNA gene repeats drive protein synthesis and genome structure, and a blueprint to develop novel genomics applications for human health, biotechnology, and agriculture.

Funded Activity Details

Start Date: 01-01-2022

End Date: 31-12-2024

Funding Scheme: Discovery Projects

Funding Amount: $637,955.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches) | Genomics | Bioinformatics | Genetics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Computer Software and Services not elsewhere classified | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Bioinformatics | Computer Software and Services not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Gene Expression (incl. Microarray and other genome-wide approaches) | Genetics | Genomics

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