Discovery Projects - Grant ID: DP210104020

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210104020

Funding Status
Active

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Funded Activity Summary

Genetic code expansion of a eukaryotic in vitro translation system. The genetic code programs biosynthesis of polypeptides with efficiency vastly superior to chemical engineering. As the chemical diversity of natural amino acids in proteins is limited, finding ways to include “unnatural” amino acids can supercharge biology with a range of new protein activities. While the genetic code can be expanded to make space for unnatural amino acids, the rarity of free codons and reliance on prokaryotic organisms limit the applicability of this approach. We will develop a new higher-organism cell-free protein production system that can incorporate multiple unnatural amino acids into defined points of proteins. This, enabling and broadly applicable technology, will be tested by constructing opioid biosensors.

Funded Activity Details

Start Date: 01-01-2021

End Date: 31-12-2024

Funding Scheme: Discovery Projects

Funding Amount: $570,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Biochemistry and Cell Biology | Synthetic Biology | Organic Chemistry not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Substance Abuse | Expanding Knowledge in the Biological Sciences | Law Enforcement |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Law Enforcement | Organic Chemistry not elsewhere classified | Proteins and Peptides | Substance Abuse | Synthetic Biology

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