Discovery Projects - Grant ID: DP210103263

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210103263

Funding Status
Active

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Funded Activity Summary

The macrophage nucleus - its form and function during migration in vivo. As cells migrate through tissues, they encounter complex, 3-dimensional environments that provide cues to guide them and present obstacles in their path. This project focuses on macrophages, a large immune cell capable of both amoeboid and mesenchymal modes of migration. The nucleus is the largest organelle and its bulk and stiffness must be managed as migrating cells travel through constrictions. The project uses specialised high-end microscopy and genetic methods to examine how the nucleus of migrating zebrafish macrophages deforms, repositions and is restructured during migration in living tissues, and how this influences macrophage locomotion. The goal is to provide fundamental insights into the cell biology of macrophage migration.

Funded Activity Details

Start Date: 04-08-2021

End Date: 03-08-2024

Funding Scheme: Discovery Projects

Funding Amount: $389,962.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Cell Physiology | Medical Physiology | Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Cell Physiology | Cellular Interactions (incl. Adhesion, Matrix, Cell Wall) | Expanding Knowledge in the Biological Sciences | Innate Immunity | Medical Physiology

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