Discovery Projects - Grant ID: DP210102405

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210102405

Funding Status
Active

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Funded Activity Summary

Uncovering the molecular mechanisms of potassium channel activity. The aim of this project is to determine the mechanisms of protein-mediated potassium ion transport across cell membranes. It will combine advanced simulations, structural biology and electrophysiology to describe the detailed molecular processes underscoring calcium-activated potassium channel conduction, gating and inactivation. The expected outcome is an improved description of how ion channels recognise and respond to physiological stimuli to control electrical signalling the body. Our results will provide benefits in the form of basic understanding relevant to ion transport phenomena in biological systems, and atomic-level views of nervous system function to guide future directions in pharmacology.

Funded Activity Details

Start Date: 14-05-2021

End Date: 13-05-2024

Funding Scheme: Discovery Projects

Funding Amount: $438,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling) | Biological Physics

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Biochemistry and Cell Biology | Biological Physics | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Structural Biology (incl. Macromolecular Modelling)

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