Discovery Projects - Grant ID: DP210102180

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210102180

Funding Status
Active

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Funded Activity Summary

CRISPR-based pathway activation for bioactive molecule discovery in fungi. Fungi produce an incredible array of unique bioactive molecules, many of which have contributed greatly to humanity (e.g. the antibiotic penicillin, which has saved millions of lives since its discovery). DNA sequencing has revealed many fungi contain the genetic instructions to produce new molecules that have not been seen previously. However, these genes are “switched off" by default and cannot be accessed. This project will develop innovative new methods to "hot-wire" these genes, allowing them to turn on and produce a treasure trove of new bioactive molecules. The outcomes of this project will transform our abilities to tap into the hidden potential of fungi to generate new lead molecules for the agricultural and medical industries.

Funded Activity Details

Start Date: 18-01-2021

End Date: 08-03-2024

Funding Scheme: Discovery Projects

Funding Amount: $543,738.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Synthetic Biology | Biologically Active Molecules

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Crop Protection Chemicals | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Biologically Active Molecules | Crop Protection Chemicals | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Synthetic Biology

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