Discovery Projects - Grant ID: DP210101632

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210101632

Funding Status
Active

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Funded Activity Summary

Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry. The aim is to gain insights into the bioinorganic chemistry that occurs when immune system cells encounter pathogens and the soles of virulence factors and immune system enhancing roles of metal ions. Pathogenic bacteria and fungi accumulate chromium (Cr) in their membranes/outer capsules, which we discovered is likely to be a previously unknown, but important, virulence factor. Hyperaccummulation of nickel (Ni) is also involved in virulence, whereas vanadium (V) enhances the immune system response to these pathogens. Fundamental insights into these roles of Cr, Ni and V will be investigated using advanced spectroscopic, imaging and biochemical techniques. These insights will provide new knowledge on the innate immune system.

Funded Activity Details

Start Date: 01-03-2021

End Date: 28-02-2024

Funding Scheme: Discovery Projects

Funding Amount: $600,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology | Inorganic Chemistry | Bioinorganic Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Bioinorganic Chemistry | Cellular Immunology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Medical and Health Sciences | Inorganic Chemistry

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