Discovery Projects - Grant ID: DP210101504

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210101504

Funding Status
Active

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Funded Activity Summary

Probing the role of dynamics in protein modulation of GPCR phenotype . Life relies upon the fundamental ability to convert external stimuli into an appropriate biological response. Such stimuli are transmitted by cell surface proteins (receptors), which convert this stimulus into an intracellular signal. The largest group of cell surface receptors is the G protein-coupled receptor (GPCR) family. Despite advances in GPCR structure determination, many questions regarding the structural basis of GPCR function and signalling remain unanswered. The primary outcome of this project is to provide mechanistic insight into the dynamics of GPCR ligand recognition and activation to advance our understanding of GPCR signal transduction, a fundamental biological process for all living organisms.

Funded Activity Details

Start Date: 01-06-2021

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $645,190.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Basic Pharmacology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling) |

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Basic Pharmacology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Human Pharmaceutical Treatments (e.g. Antibiotics) | Pharmacology and Pharmaceutical Sciences | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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